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TECHNE Corporation (NASDAQ: TECH), incorporated in Minnesota in 1981, is a holding company which has two wholly-owned
operating subsidiaries: Research and Diagnostic
Systems, Inc. (R&D Systems) located in Minneapolis, Minnesota and R&D
Systems Europe Ltd. (RDSE) located in Abingdon, England. R&D Systems is a
specialty manufacturer of biological products. It has two operating divisions:
Hematology and Biotechnology. The Hematology Division develops and manufactures
hematology controls, which are used in hospitals and clinical laboratories to
check the accuracy of blood analysis instruments. The Biotechnology Division
develops and manufactures biotechnology products including purified proteins
(cytokines) and antibodies that are sold primarily to the research
market, and assay kits which are sold to the research and clinical diagnostic
markets. Over 95% of TECHNE’s revenues are derived from products manufactured
by R&D Systems. R&D Systems has two subsidiaries: R&D Systems China Co.
Ltd. and BiosPacific, Inc. RDSE sells and distributes
R&D
Systems' biotechnology products in Europe. RDSE has a German sales subsidiary,
R&D
Systems GmbH.
R&D Systems was founded and incorporated in 1976 in Minneapolis, Minnesota
and was acquired by TECHNE in 1985. In 1977 R&D Systems introduced its
first product, a Platelet-Rich-Plasma control. In 1981 R&D Systems was
the second manufacturer in the world to release a Whole Blood Control with
Platelets, thereby establishing itself as one of the leaders in the field
of hematology control products manufacturing. Subsequently, R&D Systems
has developed several types of hematology controls designed to keep pace
with the technology of the newest models of hematology instruments. These
products are sold throughout the United States directly by R&D Systems
and in many foreign countries through distributors. Hematology products account
for approximately 7% of TECHNE revenues.
In 1985 R&D Systems entered the research reagent market with its first
cytokine, TGF-beta1, which was purified from porcine platelets. R&D Systems
was the first company in the world to release TGF-beta1 commercially. Subsequently
several other cytokines were purified from natural sources and released to
the research market. Cytokines are specialized protein molecules that are
involved in cell-to-cell communications, cell growth, cell death and differentiation,
control of the immune system and in many diseases including cancer, AIDS
and autoimmune diseases. Cytokines are in demand by biomedical researchers
who want to learn more about their diverse effects.
Encouraged by its success in the cytokine market, in 1988 R&D Systems
formed its Biotechnology Division with the goal of producing and marketing
a wide range of human cytokines through genetic engineering. Recombinant
DNA technology offers several advantages over extraction of these proteins
from natural sources, including lower production cost and potentially unlimited
supply. In 1989 the Biotechnology Division began developing monoclonal and
polyclonal antibodies to cytokines and in 1990 it developed its first enzyme-linked
immunosorbent (ELISA) assay kit.
In 1991, R&D Systems purchased Amgen Inc.'s research reagent and diagnostic
assay kit business. With this purchase, R&D Systems obtained Amgen's
Erythropoietin (EPO) kit, its first ELISA assay kit for a cytokine that had
been cleared by the FDA for clinical diagnostic use. In 1998, R&D Systems
purchased Genzyme Corporation's research products business. This acquisition
established R&D Systems as the world's leading supplier of research and
diagnostic cytokine products. Today, the Biotechnology Division manufactures
over 20,000 products.
TECHNE purchased its European biotechnology distributor, British Bio-technology
Products Ltd. (renamed R&D Systems Europe, Ltd.) from British Biotechnology
Group plc in 1993. RDSE sells and distributes R&D Systems biotechnology
products throughout Europe and parts of Asia and Africa. As a result of growth
in the European market, RDSE opened a sales office, R&D Systems GmbH,
in Germany in 1995. RDSE and its German subsidiary account for approximately
27% of TECHNE revenues.
In 2005, R&D Systems acquired Fortron Bio Science, Inc., a developer
and manufacturer of monoclonal and polyclonal antibodies, antigens and other
biological reagents. R&D Systems simultaneously acquired BiosPacific, Inc,
a worldwide supplier of biologics to manufacturers of in vitro diagnostic
systems (IVDs) and immunodiagnostic kits. BiosPacific is the primary distribution
arm of Fortron. Fortron and BiosPacific had shared a unique strategic relationship
since 1992 that combined Fortron's development and manufacturing excellence
with BiosPacific's marketing and sales expertise. The acquisitions have enhanced
R&D Systems' ability to serve the diagnostics industry. Forton was merged
into R&D Systems Biotechnology Division in July 2007. During 2007, R&D Systems
established R&D Systems China Co. Ltd., in Shanghai. The subsidiary will
provide warehousing, marketing, sales and technical services for the growing
Chinese market.
The earnings per share listed above reflects post-split shares
after the two-for-one stock split of December 2000.
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